“Mushrooms have many helpful nutrients, including beta glucans for immune enhancement, ergothioneines for antioxidative potentiation, nerve growth stimulators for helping brain function, and antimicrobial compounds for limiting viruses.” ~ Paul Stamets • Niacin • Antioxidants such as ergothioneine, glutathione • Macronutrients: protein and complex carbohydrates polyphenols • Superoxide dismutase • Prebiotic fiber • More protien than most vegetables immunity. Beta-glucans act on a diversity of immune related receptors, in particular dectin-1 and CR3, and can trigger a wide spectrum of immune responses. Dectin-1, which is a type II transmembrane protein receptor that binds 1-3-beta glucans and 1-6-beta-glucans, can initiate and regulate the innate immune response. It triggers effective immune responses including phagocytosis and pro- inflammatory factors production, leading to the elimination of infectious agents.* Terpenoids Although polysaccharides—and beta-glucans specifically— are the most important ingredient to look for in mushroom supplements, they are certainly not the only ones. Aſter polysaccharides, the second-most important active ingredients in medicinal mushrooms are terpenoids. Not to be confused with their parent compound terpenes, terpenoids are natural compounds produced by many different organisms, including mushrooms. In particular, diterpenoids, triterpenoids, and sesquiterpenoids are known to have medicinal properties. In fact, terpenoids seem to share many of the same medicinal benefits as beta- glucans, such as boosting immune system function. Terpenoids are known to show anti-infectious and anti-inflammatory activities. One important thing to keep in mind with terpenoids is that they are not water-soluble. For this reason, they must be extracted from the chosen mushroom through alcohol extraction. Alcohol extraction is typically done as an additional step aſter hot water extraction, which is why it is called a dual extract, and is necessary for mushrooms like Reishi and Chaga. Vitamins & Minerals • B vitamins (B2, B3, folate, B5) • Phosphorus • Vitamin D (only if grown in sunlight) • Selenium • Copper • Potassium • Riboflavin Low in Calories, Carbohydrates, fat, sodium and cholesterol-free. EXTRACTING THE MEDICINE The fruiting body of mushrooms contains some compounds that can be extracted with hot water (beta-glucans and enzymes) and some that need to be extracted in alcohol (triterpenes) like Reishi. Mushroom extracts should go through a double-triple hot water extraction process (plus alcohol for Reishi) in order to extract all of the beneficial compounds. Extracts should not include the substrate they are grown on or the mycelium. HOW IT HELPS OUR PETS I use mushrooms most when dealing with cancer and old age, and the degenerative diseases that come with it. Years of research from all over the world prove whole-mushroom extracts from the fruiting bodies contain compounds that modulate tumorigenesis and carcinogenesis at different stages. Because they have many different mechanisms and modes of action on cancer cells and the immune system, medicinal mushrooms could potentially provide additive or even synergistic effects in the prevention and treatment of cancer. Uses: • All Cancer • Canine Cognitive Disorder (Alzheimer’s) • Liver disease • Kidney disease • Heart disease • Respiratory support • Immune system deficiencies • Bacterial and fungal infections • Side-effects from vaccines, drugs, chemotherapy, and chemicals • Weakness and degeneration in geriatric pets • Acute and chronic cystitis • Autoimmune diseases • IVDD • Nervous System • Mental and emotional support See mushroom charts on pages 13 & 15 for complete list of uses. FOR MORE INFORMATION VISIT MYCODOG.COM *Powell M. Medicinal mushrooms: The essential guide. Mycology Press, 2013, Guggenheim AG, Wright KM, Zwicky HL. Immune modulation from five major mushrooms: application of integrative oncology. Integrative Med 2014;13(1):32-44, Kidd PM. The use of mushroom glucans and proteoglycans in cancer treatment. AMR 2000;5(1):4-27, Chi-Fung Chan G, Chan WK, Man-Yuen Sze D. The effects of β-glucan on human immune and cancer cells. J Hematol Oncol 2009;2:25, Rop O, Vlcek J, Jurikova T. Beta-glucans in higher fungi and their health effects. Nut Rev 2009;67(11):624-631, Dalonso N, Goldman GH, Gern RMM. β-(1-3),(1-6)-glucans: medicinal activities, characterization, biosynthesis and new horizons. Apple Microbial Biotechnol 2015:DOI 10.1007, Bisen PS, Bagel RK, Sanodiya BS, et al. Lentinus edodes: a macrofungus with pharmacological activities. Cur Med Chemistry 2010;17:2419-2430., Drori A, Shabat Y, Ben Ya’acov A, et al. Extracts from Lentinula edodes (shiitake) edible mushrooms enriched with vitamin D exert an anti-inflammatory hepatoprotective effect. J Med Food 2016;19(4):383-389, Torkelson CJ, Sweet E, Marten MR, et al. Phase 1 clinical trial of Trametes versicolor in women with breast cancer. ISRN Oncology 2012 (2012):ID 251632.
